Andexanet alfa mechanism of action5/28/2023 Pharmacology description/mechanism of action. 2015 Dec 17 373(25):2413-24.Ĭonnolly SJ, Milling TJ, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Goodman S, Leeds J, Wiens BL, Siegal DM, Zotova E, Meeks B, Nakamya J, Lim WT, Crowther M, ANNEXA-4 Investigators Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors. Introduction: Andexanet alfa is a recombinant modified factor Xa protein that has been developed to reverse factor Xa inhibitors. Andexanet Alfa Andexxa First line reversal of anticoagulation from apixaban, rivaroxaban, or edoxaban with life-threatening bleeding Andexanet alfa binds and sequesters the FXa inhibitors rivaroxaban and apixaban. Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity. Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS, Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA. 2021 May 5(4):e12518.Īndexxa-an antidote for apixaban and rivaroxaban. A meta-analysis of andexanet alfa and prothrombin complex concentrate in the treatment of factor Xa inhibitor-related major bleeding. Jaspers T, Shudofsky K, Huisman MV, Meijer K, Khorsand N.
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